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Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress

Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress

Lisa Y Maeng, Mohammed R Milad First Published June 27, 2017 Review Article  https://doi.org/10.1177/2470547017713297   Abstract Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition that can develop following a physical, psychological, or sexual trauma. Despite the growing body of literature examining the psychological and biological factors involved in PTSD psychopathology, specific biomarkers that may improve diagnosis and treatment of PTSD have yet to be identified and validated. This challenge may be attributed to the diverse array of symptoms that…

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Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment

Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment

Eric A.Fertuckabc JackGrinbandbcd J. JohnMannbc JoyHirschde KevinOchsnerf PaulPilkonisg JeffErbeac BarbaraStanleybc https://doi.org/10.1016/j.nicl.2018.101616Get rights and content Under a Creative Commons license open access Highlights •BPD is associated with sensitivity to signals of interpersonal betrayal and misplaced trust in others. •BPD subjects judged faces to be less trustworthy than controls. •Amygdala activity did not correlate with trustworthiness, but was modulated robustly by fearfulness of the stimulus. •Prefrontal cortex, not amygdala, was modulated by trustworthiness. •BPD was associated with reduced prefrontal activity, and the…

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Dialectical behavior therapy alters emotion regulation and amygdala activity in patients with borderline personality disorder

Dialectical behavior therapy alters emotion regulation and amygdala activity in patients with borderline personality disorder

J Psychiatr Res. Author manuscript; available in PMC 2014 Dec 11. Published in final edited form as: J Psychiatr Res. 2014 Oct; 57: 108–116. Published online 2014 Jul 2. doi: 10.1016/j.jpsychires.2014.06.020 PMCID: PMC4263347 NIHMSID: NIHMS646634 PMID: 25038629 Marianne Goodman,a,b,d,* David Carpenter,c Cheuk Y. Tang,c Kim E. Goldstein,a Jennifer Avedon,b Nicolas Fernandez,b Kathryn A. Mascitelli,b Nicholas J. Blair,b Antonia S. New,a,b Joseph Triebwasser,a,d Larry J. Siever,a,b,d and Erin A. Hazletta,b Author information Copyright and License information Disclaimer The publisher’s final edited version…

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Psychopathy: cognitive and neural dysfunction

Psychopathy: cognitive and neural dysfunction

Dialogues Clin Neurosci. 2013 Jun; 15(2): 181–190. PMCID: PMC3811089 PMID: 24174892 R. James R. Blair, PhD* Author information Copyright and License information Disclaimer This article has been cited by other articles in PMC. Abstract Psychopathy is a developmental disorder marked by emotional deficits and an increased risk for antisocial behavior. It is not equivalent to the diagnosis Antisocial Personality Disorder, which concentrates only on the increased risk for antisocial behavior and not a specific cause—ie, the reduced empathy and guilt…

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Antisocial Personality Disorders

Antisocial Personality Disorders

  Glenn, A.L. & Raine, A. (2011). Antisocial Personality Disorders. In J. Decety & J. Cacioppo (Eds.) The Oxford Handbook of Social Neuroscience (pp. 885-894). New York: Oxford University Press.     Antisocial Personality Disorders Andrea L. Glenn1  & Adrian Raine2 1Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, United States 2Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, United States   Abstract Neuroscience research is beginning to uncover…

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