Atypical Antipsychotics as Augmentation Therapy in Anorexia Nervosa

Atypical Antipsychotics as Augmentation Therapy in Anorexia Nervosa

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Open Access Peer-reviewed Research Article Enrica Marzola, Nadia Desedime, Cristina Giovannone, Federico Amianto, Secondo Fassino, Giovanni Abbate-Daga Published: April 29, 2015 https://doi.org/10.1371/journal.pone.0125569 Abstract Anorexia nervosa (AN) is a life-threatening and difficult to treat mental illness with the highest mortality rates of any psychiatric disorder. We aimed to garner preliminary data on the real-world use of olanzapine and aripiprazole as augmentation agents of Selective Serotonin Reuptake Inhibitors (SSRIs) in adult inpatients affected by AN. We retrospectively evaluated the clinical charts of…

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Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder

Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder

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Open Access Peer-reviewed Research Article Luca Passamonti , Graeme Fairchild, Alex Fornito, Ian M. Goodyer, Ian Nimmo-Smith, Cindy C. Hagan, Andrew J. Calder Published: November 7, 2012 https://doi.org/10.1371/journal.pone.0048789 Abstract Objective Previous research suggested that structural and functional abnormalities within the amygdala and orbitofrontal cortex contribute to the pathophysiology of Conduct Disorder (CD). Here, we investigated whether the integrity of the white-matter pathways connecting these regions is abnormal and thus may represent a putative neurobiological marker for CD. Methods Diffusion Tensor…

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Stable self-serving personality traits in recreational and dependent cocaine users

Stable self-serving personality traits in recreational and dependent cocaine users

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Open Access Peer-reviewed Research Article Boris B. Quednow, Lea M. Hulka, Katrin H. Preller, Markus R. Baumgartner, Christoph Eisenegger, Matthias Vonmoos Published: March 2, 2017 https://doi.org/10.1371/journal.pone.0172853 Abstract Chronic cocaine use has been associated with impairments in social cognition, self-serving and antisocial behavior, and socially relevant personality disorders (PD). Despite the apparent relationship between Machiavellianism and stimulant use, no study has explicitly examined this personality concept in cocaine users so far. In the frame of the longitudinal Zurich Cocaine Cognition Study,…

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Dispositional and ideological factor correlate of conspiracy thinking and beliefs

Dispositional and ideological factor correlate of conspiracy thinking and beliefs

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Open Access Peer-reviewed Research Article Jan Ketil Arnulf, Charlotte Robinson, Adrian Furnham Published: October 26, 2022 https://doi.org/10.1371/journal.pone.0273763 Abstract This study explored how the Big Five personality traits, as well as measures of personality disorders, are related to two different measures of conspiracy theories (CTs)The two measures correlated r = .58 and were applied to examine generalisability of findings. We also measured participants (N = 397) general knowledge levels and ideology in the form of religious and political beliefs. Results show…

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Translating trait to state assessment: The case of grandiose narcissism

Translating trait to state assessment: The case of grandiose narcissism

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Open Access Peer-reviewed Research Article Fien Heyde , Bart Wille, Evy Kuijpers, Jasmine Vergauwe, Joeri Hofmans Published: May 1, 2023 https://doi.org/10.1371/journal.pone.0284649 Abstract Although interest in within-person variability in grandiose narcissism is growing, measurement tools are lacking that allow studying fluctuations in this personality characteristic in a differentiated manner (i.e., distinguishing narcissistic admiration and rivalry). This study explores whether a measurement approach using the six-item version of the Narcissistic Grandiosity Scale (NGS Rosenthal et al. (2007)) and six additional newly formulated…

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Pain perception in personality disorders

Pain perception in personality disorders

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Open Access Peer-reviewed Research Article Spyridoula Bourtzoni, Phil Reed Published: May 9, 2025 https://doi.org/10.1371/journal.pone.0323004 Abstract Research has focused on pain perception of individuals with Borderline Personality Disorder, but there is a lack of research regarding pain perception for other types of Personality Disorders. The present study explored associations between the perception of experimentally-induced acute pain of individuals without acute or chronic pain with Borderline, as well as Histrionic, and Schizotypal, Personality Disorders traits. The primary question of interest was whether…

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Striking Discrepancy of Anomalous Body Experiences with Normal Interoceptive Accuracy in Depersonalization-Derealization Disorder

Striking Discrepancy of Anomalous Body Experiences with Normal Interoceptive Accuracy in Depersonalization-Derealization Disorder

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Open Access Peer-reviewed Research Article Matthias Michal , Bettina Reuchlein, Julia Adler, Iris Reiner, Manfred E. Beutel,Claus Vögele, Hartmut Schächinger, André Schulz Published: February 27, 2014 https://doi.org/10.1371/journal.pone.0089823 Abstract Background Disembodiment is a core feature of depersonalization disorder (DPD). Given the narratives of DPD patients about their disembodiment and emotional numbing and neurobiological findings of an inhibition of insular activity, DPD may be considered as a mental disorder with specific impairments of interoceptive awareness and body perception. Methods We investigated cardioceptive…

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A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder

A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder

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Open Access Peer-reviewed Research Article Sagari Sarkar, Flavio Dell’Acqua, Seán Froudist Walsh, Nigel Blackwood, Stephen Scott, Michael C. Craig, Quinton Deeley, Declan G. M. Murphy Published: June 6, 2016 https://doi.org/10.1371/journal.pone.0155475 Abstract Background The biological basis of severe antisocial behaviour in adolescents is poorly understood. We recently reported that adolescents with conduct disorder (CD) have significantly increased fractional anisotropy (FA) of the uncinate fasciculus (a white matter (WM) tract that connects the amygdala to the frontal lobe) compared to their non-CD…

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Personality and psychopathological characteristics in functional movement disorders

Personality and psychopathological characteristics in functional movement disorders

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Open Access Peer-reviewed Research Article Antonina Luca, Tiziana Lo Castro, Giovanni Mostile, Giulia Donzuso, Calogero Edoardo Cicero, Alessandra Nicoletti, Mario Zappia Published: May 10, 2024 https://doi.org/10.1371/journal.pone.0303379 Abstract Introduction Aim of the present study was to assess personality and psychopathological characteristics in patients with functional movement disorders (FMDs) compared to patients with other neurological disorders (OND).   Methods In this cross-sectional study, patients affected by clinically established FMDs and OND who attended the Neurologic Unit of the University-Hospital “Policlinico-San Marco” of…

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Psychopathic tendencies are selectively associated with reduced emotional awareness in the context of early adversity

Psychopathic tendencies are selectively associated with reduced emotional awareness in the context of early adversity

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Open Access Peer-reviewed Research Article Ryan Smith ,Anne E. Chuning, Colin A. Tidwell, John J. B. Allen, Richard D. Lane Published: December 22, 2022 https://doi.org/10.1371/journal.pone.0277475 Abstract It is unclear at present whether psychopathic tendencies are associated with lower or higher levels of emotional awareness (EA). Given that psychopathy includes a proficiency for manipulating others, one might expect an elevated ability to identify and use information about others’ emotions. On the other hand, empathic deficits in psychopathy could arise from reduced…

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