Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork
Open Access Peer-reviewed Research Article Jian Li, Wei-Qun Lu, Stephen Beesley, Andrew S. I. Loudon , Qing-Jun Meng Published: March 12, 2012 https://doi.org/10.1371/journal.pone.0033292 Abstract Lithium salt has been widely used in treatment of Bipolar Disorder, a mental disturbance associated with circadian rhythm disruptions. Lithium mildly but consistently lengthens circadian period of behavioural rhythms in multiple organisms. To systematically address the impacts of lithium on circadian pacemaking and the underlying mechanisms, we measured locomotor activity in mice in vivo following chronic lithium…