Modeling vulnerability and intervention targets in the Borderline Personality Disorder system: A network analysis of in silico and in vivo interventions
Open Access Peer-reviewed Research Article Said Jiménez , Iván Arango de Montis, Eduardo A. Garza-Villarreal Published: July 31, 2023 https://doi.org/10.1371/journal.pone.0289101 Abstract Modeling psychopathology as a complex dynamic system represents Borderline Personality Disorder (BPD) as a constellation of symptoms (e.g., nodes) that feedback and self-sustain each other shaping a network structure. Through in silico interventions, we simulated the evolution of the BPD system by manipulating: 1) the connectivity strength between nodes (i.e., vulnerability), 2) the external disturbances (i.e., stress) and 3)…