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Category: Trauma & Stress Disorders

Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment

Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment

Open Access Peer-reviewed Research Article Hélène Villain , Aïcha Benkahoul , Philippe Birmes, Barbara Ferry, Pascal Roullet Published: January 19, 2018 https://doi.org/10.1371/journal.pone.0191563 Abstract Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event. Currently, pharmacological treatments are limited by high rates of relapse, and novel treatment approaches are needed. We have recently demonstrated that propranolol, a β-adrenergic antagonist, inhibited aversive memory reconsolidation in animals. Following this, in an open-label study 70% of patients with PTSD treated…

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Less Empathic and More Reactive: The Different Impact of Childhood Maltreatment on Facial Mimicry and Vagal Regulation

Less Empathic and More Reactive: The Different Impact of Childhood Maltreatment on Facial Mimicry and Vagal Regulation

Open Access Peer-reviewed Research Article Martina Ardizzi , Maria Alessandra Umiltà, Valentina Evangelista, Alessandra Di Liscia, Roberto Ravera, Vittorio Gallese Published: September 29, 2016 https://doi.org/10.1371/journal.pone.0163853 Abstract Facial mimicry and vagal regulation represent two crucial physiological responses to others’ facial expressions of emotions. Facial mimicry, defined as the automatic, rapid and congruent electromyographic activation to others’ facial expressions, is implicated in empathy, emotional reciprocity and emotions recognition. Vagal regulation, quantified by the computation of Respiratory Sinus Arrhythmia (RSA), exemplifies the autonomic…

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Post-traumatic stress disorder and self-reported outcomes after traumatic brain injury in victims of assault

Post-traumatic stress disorder and self-reported outcomes after traumatic brain injury in victims of assault

Open Access Peer-reviewed Research Article Dominic Bown, Antonio Belli, Kasim Qureshi, David Davies, Emma Toman, Rachel Upthegrove Published: February 7, 2019 https://doi.org/10.1371/journal.pone.0211684 Abstract Introduction Assault is the third most common cause of traumatic brain injury (TBI), after falls and road traffic collisions. TBI can lead to multiple long-term physical, cognitive and emotional sequelae, including post-traumatic stress disorder (PTSD). Intentional violence may further compound the psychological trauma of the event, in a way that conventional outcome measures, like the Glasgow Outcome…

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In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)

In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)

Open Access Peer-reviewed Research Article Gudrun Sartory , Jan Cwik, Helge Knuppertz, Benjamin Schürholt, Morena Lebens, Rüdiger J. Seitz, Ralf Schulze Published: March 25, 2013 https://doi.org/10.1371/journal.pone.0058150 Abstract Notwithstanding some discrepancy between results from neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD), there is broad agreement as to the neural circuit underlying this disorder. It is thought to be characterized by an exaggerated amygdalar and decreased medial prefrontal activation to which the elevated anxiety state and concomitant inadequate emotional…

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Negative emotions and personal well-being among incarcerated filicide mothers in Rwanda

Negative emotions and personal well-being among incarcerated filicide mothers in Rwanda

Open Access Peer-reviewed Research Article Jean d’Amour Muziki , Thaoussi Uwera , Japhet Niyonsenga, Augustin Nshimiyimana , Siméon Gitimbwa Sebatukura , Jean Mutabaruka Published: July 27, 2022 https://doi.org/10.1371/journal.pone.0271255 Abstract Despite the tremendous evidence of the harmful effects of maternal filicide on the lives of offenders, there is a scarcity on studies of their negative emotions and personal wellbeing especially in sub-Saharan Africa. Thus, this study was primarily aimed at assessing the prevalence of negative emotions experienced by filicide mothers and…

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Protective and vulnerability personality traits associated with PTSD diagnosis after preterm delivery

Protective and vulnerability personality traits associated with PTSD diagnosis after preterm delivery

Open Access Peer-reviewed Research Article Laurane Grand , Sabrina Hammami , Sarah Bourdon , Claudia Demarly Drumelle , Julie Auer, Anne-Catherine Rolland, Julien Eutrope , Marie Olivier Published: August 12, 2024 https://doi.org/10.1371/journal.pone.0308498 Abstract Giving birth prematurely is a traumatic event that has many consequences for the mother but also for her baby and their family. Studies have shown that about a quarter of these mothers will suffer from post-traumatic stress disorder (PTSD) as a result. This study aims to identify…

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Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population

Relationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population

Open Access Peer-reviewed Research Article Antoine Yrondi , Christophe Arbus, Djamila Bennabi, Thierry D’Amato, Frank Bellivier, Thierry Bougerol, Vincent Camus, Philippe Courtet, Olivier Doumy, Jean-Baptiste Genty, Jérôme Holtzmann, Mathilde Horn, Christophe Lancon, Marion Leboyer, Pierre-Michel Llorca, Julia Maruani, Rémi Moirand, Fanny Molière, Jean Petrucci, Raphaelle Richieri, Ludovic Samalin, Florian Stephan, Guillaume Vaiva, Michel Walter, FondaMental Advanced Centres of Expertise in Resistant Depression (FACE-DR) Collaborators , Emmanuel Haffen, Bruno Aouizerate , Wissam El-Hage Published: April 20, 2021 https://doi.org/10.1371/journal.pone.0250148 Abstract Introduction We…

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Childhood behavioral inhibition is associated with impaired mentalizing in adolescence

Childhood behavioral inhibition is associated with impaired mentalizing in adolescence

Open Access Peer-reviewed Research Article Sergi Ballespí, Ariadna Pérez-Domingo, Jaume Vives, Carla Sharp, Neus Barrantes-Vidal Published: March 29, 2018 https://doi.org/10.1371/journal.pone.0195303 Abstract Recent advances suggest that impairment in social cognition (SC) may play a role in the development of social anxiety (SA). However, very few studies have analyzed whether SA fosters poorer social-cognitive development as it leads to social avoidance. This study aimed to analyze whether retrospectively assessed behavioral inhibition (BI) (i.e., an early form of SA) in childhood is associated…

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The Mentalized Affectivity Scale (MAS): Development and validation of the Italian version

The Mentalized Affectivity Scale (MAS): Development and validation of the Italian version

Open Access Peer-reviewed Research Article Teresa Rinaldi , Ilaria Castelli, Andrea Greco, David M. Greenberg, Elliot Jurist, Annalisa Valle, Antonella Marchetti Published: April 5, 2021 https://doi.org/10.1371/journal.pone.0249272 Correction 23 Sep 2021: Rinaldi T, Castelli I, Greco A, Greenberg DM, Jurist E, et al. (2021) Correction: The Mentalized Affectivity Scale (MAS): Development and validation of the Italian version. PLOS ONE 16(9): e0257989. https://doi.org/10.1371/journal.pone.0257989 View correction Abstract This study proposes a psychometric validation of the Italian version of the Mentalized Affectivity Scale (MAS) developed by Greenberg and colleagues…

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The role of personality in posttraumatic stress disorder, trait resilience, and quality of life in people exposed to the Kiss nightclub fire

The role of personality in posttraumatic stress disorder, trait resilience, and quality of life in people exposed to the Kiss nightclub fire

Open Access Peer-reviewed Research Article Vitor Crestani Calegaro , Pedro Henrique Canova Mosele, Bianca Lorenzi Negretto, Cleonice Zatti, Angelo Batista Miralha da Cunha, Lucia Helena Machado Freitas Published: July 29, 2019 https://doi.org/10.1371/journal.pone.0220472 Abstract Objective To evaluate the relationship among personality (according to Cloninger’s psychobiological model), posttraumatic stress disorder (PTSD) symptoms, trait resilience and quality of life (QoL) in people who were exposed to the Kiss nightclub fire. Methods 188 participants were assessed with the Posttraumatic Checklist–civilian version (PCL-C), the Resilience…

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