Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment
Open Access Peer-reviewed Research Article Hélène Villain , Aïcha Benkahoul , Philippe Birmes, Barbara Ferry, Pascal Roullet Published: January 19, 2018 https://doi.org/10.1371/journal.pone.0191563 Abstract Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event. Currently, pharmacological treatments are limited by high rates of relapse, and novel treatment approaches are needed. We have recently demonstrated that propranolol, a β-adrenergic antagonist, inhibited aversive memory reconsolidation in animals. Following this, in an open-label study 70% of patients with PTSD treated…