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Category: Trauma & Stress Disorders

Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial

Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial

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Open Access Study Protocol Shakila Meshkat , Richard J. Zeifman , Kathleen Stewart , Reinhard Janssen-Aguilar, Wendy Lou, Rakesh Jetly, Candice M. Monson, Venkat Bhat Published: January 17, 2025 https://doi.org/10.1371/journal.pone.0313741 Background Posttraumatic stress disorder (PTSD) affects 3.9% of the general population. While massed cognitive processing therapy (CPT) has demonstrated efficacy in treating chronic PTSD, a substantial proportion of patients still continue to meet PTSD criteria after treatment, highlighting the need for novel therapeutic approaches. Preliminary evidence supports the potential therapeutic…

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Inter-Identity Autobiographical Amnesia in Patients with Dissociative Identity Disorder

Inter-Identity Autobiographical Amnesia in Patients with Dissociative Identity Disorder

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Open Access Peer-reviewed Research Article Rafaële J. C. Huntjens , Bruno Verschuere, Richard J. McNally Published: July 18, 2012 https://doi.org/10.1371/journal.pone.0040580 Abstract Background A major symptom of Dissociative Identity Disorder (DID; formerly Multiple Personality Disorder) is dissociative amnesia, the inability to recall important personal information. Only two case studies have directly addressed autobiographical memory in DID. Both provided evidence suggestive of dissociative amnesia. The aim of the current study was to objectively assess transfer of autobiographical information between identities in a…

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Estimating the total prevalence of PTSD among the UK police force: Formal comment on Stevelink et al. (2020)

Estimating the total prevalence of PTSD among the UK police force: Formal comment on Stevelink et al. (2020)

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Open Access Formal Comment Chris R. Brewin , Jessica K. Miller, Brendan Burchell Published: May 20, 2022 https://doi.org/10.1371/journal.pone.0268621 Abstract Two recent surveys have reported widely differing prevalence rates for posttraumatic stress disorder (PTSD) within the U.K. police force. Stevelink et al. (2020) reported a rate of 3.9% whereas a survey conducted for the charity Police Care UK reported a rate of 20.6%. In this comment we discuss how definitions and methodological factors can impact prevalence rates. We consider a number…

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Body image and appearance distress among military veterans and civilians with an injury-related visible difference: A comparison study

Body image and appearance distress among military veterans and civilians with an injury-related visible difference: A comparison study

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Mary Keeling , Diana Harcourt, Paul White, Sarah Evans, Victoria S. Williams V., James Kiff, Heidi Williamson Published: February 7, 2025 https://doi.org/10.1371/journal.pone.0305022 Abstract Injuries sustained during military conflict can significantly impact appearance. Yet, little is known about the psychosocial experiences of veterans with conflict-related appearance-altering injuries (AAI) and whether current civilian interventions are appropriate for this group. To inform the development of acceptable and effective support for veterans with appearance–related psychosocial difficulties, this study aimed to identify factors associated with…

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White Matter Microstructure Alterations: A Study of Alcoholics with and without Post-Traumatic Stress Disorder

White Matter Microstructure Alterations: A Study of Alcoholics with and without Post-Traumatic Stress Disorder

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Open Access Peer-reviewed Research Article Caitlin A. Durkee, Joelle E. Sarlls, Daniel W. Hommer, Reza Momenan Published: November 18, 2013 https://doi.org/10.1371/journal.pone.0080952 Abstract Many brain imaging studies have demonstrated reductions in gray and white matter volumes in alcoholism, with fewer investigators using diffusion tensor imaging (DTI) to examine the integrity of white matter pathways. Among various medical conditions, alcoholism and post-traumatic stress disorder (PTSD) are two comorbid diseases that have similar degenerative effects on the white matter integrity. Therefore, understanding and…

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Childhood physical abuse and subsequent violent victimization among people who use illegal drugs in Vancouver, Canada

Childhood physical abuse and subsequent violent victimization among people who use illegal drugs in Vancouver, Canada

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Open Access Peer-reviewed Research Article Julie Sagram , William Lee, JinCheol Choi, M.-J. Milloy , Kanna Hayashi , Kora DeBeck , Evan Wood , Thomas Kerr Published: August 12, 2021 https://doi.org/10.1371/journal.pone.0255875 Abstract Background Violent victimization is common among people who use illegal drugs (PWUD) and is a source of significant health-related harm. However, little attention has been paid to how antecedent childhood trauma among PWUD may contribute to the risk of victimization in adulthood. Objective This study sought to examine…

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Childhood trauma, PTSD/CPTSD and chronic pain: A systematic review

Childhood trauma, PTSD/CPTSD and chronic pain: A systematic review

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Open Access Peer-reviewed Research Article Maria Karimov-Zwienenberg , Wilfried Symphor, William Peraud, Greg Décamps Published: August 30, 2024 https://doi.org/10.1371/journal.pone.0309332 Abstract Background Despite the growing body of literature on posttraumatic stress disorder (PTSD) and chronic pain comorbidity, studies taking into account the role of childhood exposure to traumatic and adverse events remains minimal. Additionally, it has been well established that survivors of childhood trauma may develop more complex reactions that extend beyond those observed in PTSD, typically categorized as complex trauma…

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Stable self-serving personality traits in recreational and dependent cocaine users

Stable self-serving personality traits in recreational and dependent cocaine users

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Open Access Peer-reviewed Research Article Boris B. Quednow, Lea M. Hulka, Katrin H. Preller, Markus R. Baumgartner, Christoph Eisenegger, Matthias Vonmoos Published: March 2, 2017 https://doi.org/10.1371/journal.pone.0172853 Abstract Chronic cocaine use has been associated with impairments in social cognition, self-serving and antisocial behavior, and socially relevant personality disorders (PD). Despite the apparent relationship between Machiavellianism and stimulant use, no study has explicitly examined this personality concept in cocaine users so far. In the frame of the longitudinal Zurich Cocaine Cognition Study,…

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Personality and psychopathological characteristics in functional movement disorders

Personality and psychopathological characteristics in functional movement disorders

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Open Access Peer-reviewed Research Article Antonina Luca, Tiziana Lo Castro, Giovanni Mostile, Giulia Donzuso, Calogero Edoardo Cicero, Alessandra Nicoletti, Mario Zappia Published: May 10, 2024 https://doi.org/10.1371/journal.pone.0303379 Abstract Introduction Aim of the present study was to assess personality and psychopathological characteristics in patients with functional movement disorders (FMDs) compared to patients with other neurological disorders (OND).   Methods In this cross-sectional study, patients affected by clinically established FMDs and OND who attended the Neurologic Unit of the University-Hospital “Policlinico-San Marco” of…

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Suicide and sudden violent death among young people: Two sides of the same coin?

Suicide and sudden violent death among young people: Two sides of the same coin?

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Open Access Peer-reviewed Research Article Annelie Werbart Törnblom , Andrzej Werbart , Kimmo Sorjonen , Bo Runeson Published: December 4, 2024 https://doi.org/10.1371/journal.pone.0313673   Abstract The aim of the present study was to compare risk factors for death by suicide and sudden violent death (SVD) among young people aged 10–25 years. Two target samples, 63 consecutive cases of youth suicide and 62 cases of SVD, were compared on potential risk factors differentiating the two groups from 104 controls. Data on psychiatric…

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