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Tag: Conduct Disorder

Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder

Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder

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Open Access Peer-reviewed Research Article Luca Passamonti , Graeme Fairchild, Alex Fornito, Ian M. Goodyer, Ian Nimmo-Smith, Cindy C. Hagan, Andrew J. Calder Published: November 7, 2012 https://doi.org/10.1371/journal.pone.0048789 Abstract Objective Previous research suggested that structural and functional abnormalities within the amygdala and orbitofrontal cortex contribute to the pathophysiology of Conduct Disorder (CD). Here, we investigated whether the integrity of the white-matter pathways connecting these regions is abnormal and thus may represent a putative neurobiological marker for CD. Methods Diffusion Tensor…

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A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder

A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder

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Open Access Peer-reviewed Research Article Sagari Sarkar, Flavio Dell’Acqua, Seán Froudist Walsh, Nigel Blackwood, Stephen Scott, Michael C. Craig, Quinton Deeley, Declan G. M. Murphy Published: June 6, 2016 https://doi.org/10.1371/journal.pone.0155475 Abstract Background The biological basis of severe antisocial behaviour in adolescents is poorly understood. We recently reported that adolescents with conduct disorder (CD) have significantly increased fractional anisotropy (FA) of the uncinate fasciculus (a white matter (WM) tract that connects the amygdala to the frontal lobe) compared to their non-CD…

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Pain Sensitivity in Adolescent Males with Attention-Deficit/Hyperactivity Disorder: Testing for Associations with Conduct Disorder and Callous and Unemotional Traits

Pain Sensitivity in Adolescent Males with Attention-Deficit/Hyperactivity Disorder: Testing for Associations with Conduct Disorder and Callous and Unemotional Traits

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Open Access  Peer-reviewed Research Article Clare Northover, Anita Thapar, Kate Langley, Stephanie HM van Goozen Published: July 30, 2015 https://doi.org/10.1371/journal.pone.0134417 Abstract Background Reduced processing and experience of aversive emotional cues is a common component of theories on the development and persistence of aggression and antisocial behaviour. Yet physical pain, arguably the most basic aversive cue, has attracted comparatively little attention. Methods This study measured pain sensitivity and physiological response to painful stimuli (skin conductance level, SCL) in adolescent boys with…

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