Personality Traits as Risk Factors for Treatment-Resistant Depression
Open Access Peer-reviewed Research Article Michio Takahashi, Yukihiko Shirayama , Katsumasa Muneoka, Masatoshi Suzuki, Koichi Sato, Kenji Hashimoto Published: May 22, 2013 https://doi.org/10.1371/journal.pone.0063756 Abstract Background The clinical outcome of antidepressant treatment in patients with major depressive disorder (MDD) is thought to be associated with personality traits. A number of studies suggest that depressed patients show high harm avoidance, low self-directedness and cooperativeness, as measured on the Temperament and Character Inventory (TCI). However, the psychology of these patients is not well…