The links between neuroinflammation, brain structure and depressive disorder: A cross-sectional study protocol
Open Access Study Protocol Egle Milasauskiene , Julius Burkauskas, Simonas Jesmanas, Rymante Gleizniene, Vilmante Borutaite, Kristina Skemiene, Paulina Vaitkiene, Virginija Adomaitiene, Saulius Lukosevicius, Brigita Gradauskiene, Guy Brown, Vesta Steibliene Published: November 20, 2024 https://doi.org/10.1371/journal.pone.0311218 Abstract Introduction It is known that symptoms of major depressive disorder (MDD) are associated with neurodegeneration, that lipopolysaccharide (LPS) can induce symptoms of MDD, and that blood LPS levels are elevated in neurodegeneration. However, it is not known whether blood LPS and cytokine levels correlate with…