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Neurotrophic factors and hippocampal activity in PTSD

Neurotrophic factors and hippocampal activity in PTSD

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Open Access Peer-reviewed Research Article Ümit Tural , Ahmet Tamer Aker, Emin Önder, Hatice Turan Sodan, Hatice Ünver, Gür Akansel Published: May 25, 2018 https://doi.org/10.1371/journal.pone.0197889 Abstract Although numerous studies have investigated the neurotrophic factors and hippocampal activity in posttraumatic stress disorder (PTSD) separately each other, it is unclear whether an association between neurotrophic factors and hippocampal activity is present. The aim of this study was to evaluate the functional changes in hippocampus before and after treatment with escitalopram and to…

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Increased Prefrontal Cortical Thickness Is Associated with Enhanced Abilities to Regulate Emotions in PTSD-Free Women with Borderline Personality Disorder

Increased Prefrontal Cortical Thickness Is Associated with Enhanced Abilities to Regulate Emotions in PTSD-Free Women with Borderline Personality Disorder

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Open Access Peer-reviewed Research Article Hannah Bruehl , Sandra Preißler, Isabella Heuser, Hauke R. Heekeren, Stefan Roepke , Isabel Dziobek Published: June 5, 2013 https://doi.org/10.1371/journal.pone.0065584 Abstract Previous studies suggest that amygdala, insula and prefrontal cortex (PFC) disintegrity play a crucial role in the failure to adequately regulate emotions in Borderline Personality Disorder (BPD). However, prior results are confounded by the high rate of comorbidity with Posttraumatic Stress Disorder (PTSD), which itself has been associated with changes in frontolimbic circuitry. We…

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