Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment

Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment

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Open Access Peer-reviewed Research Article Hélène Villain , Aïcha Benkahoul , Philippe Birmes, Barbara Ferry, Pascal Roullet Published: January 19, 2018 https://doi.org/10.1371/journal.pone.0191563 Abstract Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event. Currently, pharmacological treatments are limited by high rates of relapse, and novel treatment approaches are needed. We have recently demonstrated that propranolol, a β-adrenergic antagonist, inhibited aversive memory reconsolidation in animals. Following this, in an open-label study 70% of patients with PTSD treated…

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Less Empathic and More Reactive: The Different Impact of Childhood Maltreatment on Facial Mimicry and Vagal Regulation

Less Empathic and More Reactive: The Different Impact of Childhood Maltreatment on Facial Mimicry and Vagal Regulation

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Open Access Peer-reviewed Research Article Martina Ardizzi , Maria Alessandra Umiltà, Valentina Evangelista, Alessandra Di Liscia, Roberto Ravera, Vittorio Gallese Published: September 29, 2016 https://doi.org/10.1371/journal.pone.0163853 Abstract Facial mimicry and vagal regulation represent two crucial physiological responses to others’ facial expressions of emotions. Facial mimicry, defined as the automatic, rapid and congruent electromyographic activation to others’ facial expressions, is implicated in empathy, emotional reciprocity and emotions recognition. Vagal regulation, quantified by the computation of Respiratory Sinus Arrhythmia (RSA), exemplifies the autonomic…

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Reliability and Construct Validity of the Psychopathic Personality Inventory-Revised in a Swedish Non-Criminal Sample – A Multimethod Approach including Psychophysiological Correlates of Empathy for Pain

Reliability and Construct Validity of the Psychopathic Personality Inventory-Revised in a Swedish Non-Criminal Sample – A Multimethod Approach including Psychophysiological Correlates of Empathy for Pain

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Open Access Peer-reviewed Research Article Karolina Sörman ,Gustav Nilsonne, Katarina Howner, Sandra Tamm, Shilan Caman, Hui-Xin Wang, Martin Ingvar, John F. Edens, Petter Gustavsson, Scott O Lilienfeld, Predrag Petrovic, Håkan Fischer, Marianne Kristiansson Published: June 14, 2016 https://doi.org/10.1371/journal.pone.0156570 Abstract Cross-cultural investigation of psychopathy measures is important for clarifying the nomological network surrounding the psychopathy construct. The Psychopathic Personality Inventory-Revised (PPI-R) is one of the most extensively researched self-report measures of psychopathic traits in adults. To date however, it has been…

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Psychophysiology of facial emotion recognition in psychopathy dimensions and oxytocin’s role: A scoping review

Psychophysiology of facial emotion recognition in psychopathy dimensions and oxytocin’s role: A scoping review

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Open Access Peer-reviewed Research Article Sara Ferreira-Nascimento , Filipa Freire, Diana Prata Published: July 30, 2025 https://doi.org/10.1371/journal.pone.0327764 Abstract Psychopathy is characterized by social impairments that hinder effective societal functioning. It comprises two main dimensions: “Interpersonal-affective” and “Lifestyle-antisocial,” each associated with distinct patterns of traits and central and peripheral neurocorrelates, particularly concerning social salience and oxytocin function. In this review, we systematically identified and synthesized evidence from studies investigating oxytocin’s role in the psychophysiological correlates of emotion recognition across psychopathy dimensions….

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Post-traumatic stress disorder and self-reported outcomes after traumatic brain injury in victims of assault

Post-traumatic stress disorder and self-reported outcomes after traumatic brain injury in victims of assault

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Open Access Peer-reviewed Research Article Dominic Bown, Antonio Belli, Kasim Qureshi, David Davies, Emma Toman, Rachel Upthegrove Published: February 7, 2019 https://doi.org/10.1371/journal.pone.0211684 Abstract Introduction Assault is the third most common cause of traumatic brain injury (TBI), after falls and road traffic collisions. TBI can lead to multiple long-term physical, cognitive and emotional sequelae, including post-traumatic stress disorder (PTSD). Intentional violence may further compound the psychological trauma of the event, in a way that conventional outcome measures, like the Glasgow Outcome…

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In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)

In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)

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Open Access Peer-reviewed Research Article Gudrun Sartory , Jan Cwik, Helge Knuppertz, Benjamin Schürholt, Morena Lebens, Rüdiger J. Seitz, Ralf Schulze Published: March 25, 2013 https://doi.org/10.1371/journal.pone.0058150 Abstract Notwithstanding some discrepancy between results from neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD), there is broad agreement as to the neural circuit underlying this disorder. It is thought to be characterized by an exaggerated amygdalar and decreased medial prefrontal activation to which the elevated anxiety state and concomitant inadequate emotional…

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The paradoxical decline and growth of trust as a function of borderline personality disorder trait count: Using discontinuous growth modelling to examine trust dynamics in response to violation and repair

The paradoxical decline and growth of trust as a function of borderline personality disorder trait count: Using discontinuous growth modelling to examine trust dynamics in response to violation and repair

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Open Access Peer-reviewed Research Article Gamze Abramov , Sebastien Miellet, Jason Kautz, Brin F. S. Grenyer, Frank P. Deane Published: July 23, 2020 https://doi.org/10.1371/journal.pone.0236170 Abstract Borderline personality disorder (BPD) is associated with paradoxical trust cognitions and behaviours. While BPD is associated with difficulty forming trust and maintaining cooperation in trust-based exchanges, design and analytical methodology best suited to reveal the temporal ebb and flow of trust have been underutilized. We used an economic game to examine the trajectories of trust…

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Quality of Life of Taiwanese Adults with Autism Spectrum Disorder

Quality of Life of Taiwanese Adults with Autism Spectrum Disorder

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Open Access Peer-reviewed Research Article Ling-Yi Lin Published: October 9, 2014 https://doi.org/10.1371/journal.pone.0109567 Abstract Background To date, few recent studies have investigated the quality of life of adults with autism spectrum disorder (ASD). It remains unclear how individuals with ASD view their own quality of life. Objective The primary purpose of this study was to compare the quality of life scores among adults with ASD with those of a non-ASD control group and the Taiwanese health population reference group. Methods The…

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Sociodemographics, Comorbidities, Healthcare Utilization and Work Productivity in Japanese Patients with Adult ADHD

Sociodemographics, Comorbidities, Healthcare Utilization and Work Productivity in Japanese Patients with Adult ADHD

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Open Access Peer-reviewed Research Article Eiji Kirino , Hideyuki Imagawa, Taro Goto, William Montgomery Published: July 6, 2015 https://doi.org/10.1371/journal.pone.0132233 Abstract Objectives This study compared the sociodemographic characteristics, comorbidities, healthcare resource utilization, and work productivity among Japanese adults who reported being diagnosed with attention-deficit/hyperactivity disorder (ADHD) to those of a non-ADHD control population. Methods Data for this study were captured from an online survey of adults in Japan conducted by Kantar Health using consumer panels. A total of 84 survey participants…

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Negative emotions and personal well-being among incarcerated filicide mothers in Rwanda

Negative emotions and personal well-being among incarcerated filicide mothers in Rwanda

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Open Access Peer-reviewed Research Article Jean d’Amour Muziki , Thaoussi Uwera , Japhet Niyonsenga, Augustin Nshimiyimana , Siméon Gitimbwa Sebatukura , Jean Mutabaruka Published: July 27, 2022 https://doi.org/10.1371/journal.pone.0271255 Abstract Despite the tremendous evidence of the harmful effects of maternal filicide on the lives of offenders, there is a scarcity on studies of their negative emotions and personal wellbeing especially in sub-Saharan Africa. Thus, this study was primarily aimed at assessing the prevalence of negative emotions experienced by filicide mothers and…

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