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Month: May 2025

Pain perception in personality disorders

Pain perception in personality disorders

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Open Access Peer-reviewed Research Article Spyridoula Bourtzoni, Phil Reed Published: May 9, 2025 https://doi.org/10.1371/journal.pone.0323004 Abstract Research has focused on pain perception of individuals with Borderline Personality Disorder, but there is a lack of research regarding pain perception for other types of Personality Disorders. The present study explored associations between the perception of experimentally-induced acute pain of individuals without acute or chronic pain with Borderline, as well as Histrionic, and Schizotypal, Personality Disorders traits. The primary question of interest was whether…

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Striking Discrepancy of Anomalous Body Experiences with Normal Interoceptive Accuracy in Depersonalization-Derealization Disorder

Striking Discrepancy of Anomalous Body Experiences with Normal Interoceptive Accuracy in Depersonalization-Derealization Disorder

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Open Access Peer-reviewed Research Article Matthias Michal , Bettina Reuchlein, Julia Adler, Iris Reiner, Manfred E. Beutel,Claus Vögele, Hartmut Schächinger, André Schulz Published: February 27, 2014 https://doi.org/10.1371/journal.pone.0089823 Abstract Background Disembodiment is a core feature of depersonalization disorder (DPD). Given the narratives of DPD patients about their disembodiment and emotional numbing and neurobiological findings of an inhibition of insular activity, DPD may be considered as a mental disorder with specific impairments of interoceptive awareness and body perception. Methods We investigated cardioceptive…

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A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder

A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder

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Open Access Peer-reviewed Research Article Sagari Sarkar, Flavio Dell’Acqua, Seán Froudist Walsh, Nigel Blackwood, Stephen Scott, Michael C. Craig, Quinton Deeley, Declan G. M. Murphy Published: June 6, 2016 https://doi.org/10.1371/journal.pone.0155475 Abstract Background The biological basis of severe antisocial behaviour in adolescents is poorly understood. We recently reported that adolescents with conduct disorder (CD) have significantly increased fractional anisotropy (FA) of the uncinate fasciculus (a white matter (WM) tract that connects the amygdala to the frontal lobe) compared to their non-CD…

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Personality and psychopathological characteristics in functional movement disorders

Personality and psychopathological characteristics in functional movement disorders

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Open Access Peer-reviewed Research Article Antonina Luca, Tiziana Lo Castro, Giovanni Mostile, Giulia Donzuso, Calogero Edoardo Cicero, Alessandra Nicoletti, Mario Zappia Published: May 10, 2024 https://doi.org/10.1371/journal.pone.0303379 Abstract Introduction Aim of the present study was to assess personality and psychopathological characteristics in patients with functional movement disorders (FMDs) compared to patients with other neurological disorders (OND).   Methods In this cross-sectional study, patients affected by clinically established FMDs and OND who attended the Neurologic Unit of the University-Hospital “Policlinico-San Marco” of…

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Psychopathic tendencies are selectively associated with reduced emotional awareness in the context of early adversity

Psychopathic tendencies are selectively associated with reduced emotional awareness in the context of early adversity

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Open Access Peer-reviewed Research Article Ryan Smith ,Anne E. Chuning, Colin A. Tidwell, John J. B. Allen, Richard D. Lane Published: December 22, 2022 https://doi.org/10.1371/journal.pone.0277475 Abstract It is unclear at present whether psychopathic tendencies are associated with lower or higher levels of emotional awareness (EA). Given that psychopathy includes a proficiency for manipulating others, one might expect an elevated ability to identify and use information about others’ emotions. On the other hand, empathic deficits in psychopathy could arise from reduced…

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Evaluation of international guidance for the community treatment of ‘personality disorders’: A systematic review

Evaluation of international guidance for the community treatment of ‘personality disorders’: A systematic review

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Open Access Peer-reviewed Research Article Nicholas Zhan Yuen Wong, Phoebe Barnett, Luke Sheridan Rains, Sonia Johnson, Jo Billings Published: March 13, 2023 https://doi.org/10.1371/journal.pone.0264239 Abstract Background Guidelines for the treatment and management of ‘personality disorders’ have been introduced to provide guidance on best practice based on evidence and views of key stakeholders. However, guidance varies and there is yet to be an overall, internationally recognised consensus on the best mental health care for people with ‘personality disorders’. Aims We aimed to…

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Association between childhood maltreatment, psychopathology and DNA methylation of genes involved in stress regulation: Evidence from a study in Borderline Personality Disorder

Association between childhood maltreatment, psychopathology and DNA methylation of genes involved in stress regulation: Evidence from a study in Borderline Personality Disorder

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Open Access Peer-reviewed Research Article Vera Flasbeck, Martin Brüne Published: March 11, 2021 https://doi.org/10.1371/journal.pone.0248514 Abstract Previous research suggests that childhood maltreatment is associated with epigenetic modification of genes involved in hypothalamic-pituitary-adrenal (HPA) functioning, which could cause dysregulation of the stress response system. If pervasive, this may be associated with the development of stress-related disorder in adults, including affective disorders, anxiety disorders, post-traumatic stress disorder (PTSD) or borderline-personality disorder (BPD). The majority of studies have focused on DNA methylation of the…

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Predictors of Natural and Unnatural Mortality among Patients with Personality Disorder: Evidence from a Large UK Case Register

Predictors of Natural and Unnatural Mortality among Patients with Personality Disorder: Evidence from a Large UK Case Register

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Open Access Peer-reviewed Research Article Marcella Lei-Yee Fok , Robert Stewart, Richard D. Hayes , Paul Moran Published: July 7, 2014 https://doi.org/10.1371/journal.pone.0100979 Abstract Background People with personality disorder have reduced life expectancy, yet, within this population, little is known about the clinical predictors of natural and unnatural deaths. We set out to investigate this, using a large cohort of secondary mental health patients with personality disorder. Methods We identified patients with an ICD-10 diagnosis of personality disorder, aged ≥15 years…

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Monitoring the emotional facial reactions of individuals with antisocial personality disorder during the retrieval of self-defining memories

Monitoring the emotional facial reactions of individuals with antisocial personality disorder during the retrieval of self-defining memories

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Open Access Peer-reviewed Research Article Audrey Lavallee, Thierry. H. Pham, Marie-Charlotte Gandolphe, Xavier Saloppé, Laurent Ott, Jean-Louis Nandrino Published: June 8, 2022 https://doi.org/10.1371/journal.pone.0268818 Abstract While a deficit in the recognition of facial expression has been demonstrated in persons with antisocial personality disorder (ASPD), few studies have investigated how individuals with ASPD produce their own emotional facial expressions. This study examines the production of facial emotional expressions of male inpatients with ASPD in a forensic hospital compared with a control group…

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Are narcissists more attracted to people in relationships than to people not in relationships?

Are narcissists more attracted to people in relationships than to people not in relationships?

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Open Access Peer-reviewed Research Article Amy B. Brunell , Joshua Robison , Nicholas P. Deems , Bradley M. Okdie Published: March 27, 2018 https://doi.org/10.1371/journal.pone.0194106 Abstract Does grandiose narcissism predict greater attraction for others in relationships? We examined this question by replicating previous work implicating grandiose narcissists as mate poachers (Studies 1 and 2). We then used an experimental paradigm (Studies 3 and 4) to assess the extent to which grandiose narcissists indicate a greater interest in someone who is already…

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